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Macrophages have been suggested to have a dual role in the suppression of cancer progression and promotion of malignancy. Macrophages are recruited to tumour tissues upon tumour initiation. Tumour-associated macrophages (TAMs) are the predominant population of inflammatory cells in tumours and are mainly activated by cytokines secreted by cancer cells. In contrast to the anti-inflammatory M2 phenotype, the pro-inflammatory M1 phenotype is positively correlated with poor prognosis in cancer patients. Therefore, TAMs should be considered an immunological hallmark of cancer. Macrophages play a key role in the early tumour microenvironment, modulating the tum ac619d1d87
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